Descripción
Modelos de Hodgkin-Huxley y de integración y disparo; redes neuronales biológicas y plasticidad sináptica; codificación neural y procesamiento sensorial; dinámica del crecimiento tumoral avascular y vascular; angiogénesis; invasión tisular y metástasis; heterogeneidad tumoral; modelos de radioterapia, quimioterapia e inmunoterapia; control óptimo de tratamientos; resistencia a drogas en cáncer; otros afines.
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Paulo Fernando de Arruda Mancera (UNESP)5/10/26, 14:30Neurociencia matemática – Oncología matemáticaPresentación Oral
The term “cancer” encompasses a range of diseases characterized by uncontrolled cell proliferation and the potential to metastasize (National Cancer Institute (INCA), What Is Cancer?, Ministry of Health, 2023). Although widely used, traditional approaches such as chemotherapy, radiation therapy, and surgery face limitations, including systemic toxicity, low specificity, the development of...
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Sr. Juan Daniel Huancas Gallardo (Universidad del Bío Bío)5/10/26, 14:50Neurociencia matemática – Oncología matemáticaPresentación Oral
Chimeric Antigen Receptor T-cell therapy, known as CAR-T cell therapy,
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constitutes one of the most recent and innovative strategies in cancer
immunotherapy. This therapy consists of genetically modifying a patient's own
T lymphocytes so that they express chimeric receptors capable of recognizing
specific antigens present on tumor cells. However, its long-term efficacy
remains limited by... -
Carola Gatica (Universidad del Bío Bío)5/10/26, 15:10Neurociencia matemática – Oncología matemáticaPresentación Oral
In this work, we study a new three-dimensional mathematical model of cancer that describes the interaction between tumor cells, immune system effector cells, and the cytokine IL-2 in patients undergoing immunotherapy. The model accounts for both functional exhaustion and the depletion of effector cells, as well as their proliferation induced by tumor stimulation, thereby capturing relevant...
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